Angioneurotic Œdema Produced by Sulphathiazole

A Hindu male, aged 25, was given sulphathiazole for nasal sinusitus after a common cold; first dose (4 tablets) given at night. Late at night he woke up with itchiness of the scalp and in the morning he had puffiness and oedema of the face and scalp (giving a wrinkled baggy appearance to the face). It was soon relieved by an injection of adrenalin. No more of the sulpha-drug was taken.' A year later the same treatment was followed by the same result. The patient has a family history of asthma and has himself suffered occasionally from such attacks, lasting for a variable period. The second time, he was actually in such an attack. No other drug was being administered on either of these occasions. He has not suffered from